Synthesis of Biologically Active 4-Arylideneamino-2,4-dihydro-3H-1,2,4-triazol-3- one Compound by Ultrasonic Radiation and Conventional Method, Comparison of Methods and Elucidation of Structure

Today, the majority of drugs used in treatment diseases are obtained by synthesis. A large proportion compounds have heterocyclic structure. Therefore, synthesis new has always attracted and continues to attract scientist. It is known that bearing triazole skeleton an important place. The reactions 4-amino-triazole compounds, especially with aromatic aldehydes, been for a long time this reaction carried out conventional heating methods. However, development alternative methods these also recently studied. One most organic microwave method it widely used. Another realization ultrasonic radiation. Ultrasound-assisted environmentally friendly, modern economical accelerate reactions. In study, optimum conditions were determined using radiation results compared classical method. For purpose, first step iminoester was synthesized Pinner ethylcarbazate gave corresponding hydrazone. Then hydrazone derivative hydrazine hydrate, 4-amino-1,2,4-triazole compound synthesized. final step, interaction amino 3-bromo-4-fluorobenzaldehyde novel (ultrasonic radiation) obtain targeted imine compound. chemical structure will be spectroscopic such as 1H- 13C-NMR IR. terms time, yield purity between And we found much more advantageous.